Chronic Pain: The Neurotransmitter Connection

Dr. Andrew Damian

12/18/2022

Chronic Pain: The Neurotransmitter Connection

Chronic pain is a complex phenomenon that is not fully understood, but it is thought to be related to changes in the nervous system.

There are several neurotransmitters that play a role in the experience of chronic pain, including:

Serotonin: Serotonin is a neurotransmitter that is involved in the regulation of mood, sleep, and pain. Low levels of serotonin have been associated with an increased risk of chronic pain.
Norepinephrine: Norepinephrine is a neurotransmitter that is involved in the body's stress response. It can affect pain perception and has been linked to the development of chronic pain.
Substance P: Substance P is a neurotransmitter that is involved in the transmission of pain signals from the periphery to the brain. It has been linked to the development of chronic pain, especially in cases of neuropathic pain.
Glutamate: Glutamate is a neurotransmitter that is involved in the transmission of pain signals and the regulation of inflammation. Elevated levels of glutamate have been linked to the development of chronic pain.
Endocannabinoids: Endocannabinoids are neurotransmitters that are involved in the regulation of pain and inflammation. They are produced by the body and can be influenced by the use of marijuana, which contains the psychoactive compound THC.

It's important to note that the role of these neurotransmitters in chronic pain is complex and not fully understood. Further research is needed to fully understand the underlying mechanisms of chronic pain and to develop effective treatments.

Recent Posts

Biofeedback Therapy Near Me: What Conditions Can It Treat?

Our Team04/05/2026

Explore what conditions biofeedback therapy in Oakland, CA treats and how it supports pain relief, stress control, and improved mind-body balance.

Slow Diaphragmatic Breathing Heals Your Mind and Body

Dr. Andrew Damian01/11/2026

Breathing balances your autonomic nervous system, it moves lymphatic fluids, and it even changes your brain.

Neurofeedback Therapy: How It Works and Who It Helps

Our Team12/01/2025

Neurofeedback therapy for mental health gives your brain an opportunity to relearn stable patterns with guidance and support from our professionals.

I worked with Andrew managing chronic pain stemming from orthopedic issues that emerged in my early 30s. I'd developed a very unhealthy cycle of pain, anxiety, and depression. Andrew's approach really helped me understand how my pain, and my socio-emotional state, were related, and allowed me to break free of negative cycles of pain. His approach of using education about the science of pain, combined with talk therapy, was exactly what I needed to both get a handle on my pain, and to move forward with a set of mindsets and solutions to both my pain, and broader emotional and identity challenges in my life. His multi-faceted, and highly professional approach to chronic pain and emotional wellbeing was both unique, and highly effective. Every time I met with Andrew, I knew I would receive sensitive, honest, and evidence-based support in addressing my chronic pain, and other interrelated life challenges.

S.F. Office Visit

In March 2023, I began working with Dr. Andrew Damian after years of struggling with intense chronic pain. It felt like I was trapped in a relentless cycle of fear, pain, and self-doubt—like my body had turned against me and knew exactly how to hurt me. Despite consulting numerous neurologists, physical therapists, primary care providers, chiropractors, psychologists, and psychiatrists, I never received any clear answers or meaningful relief. Medical doctors prescribed nerve blockers to mask the pain, but they didn’t address the root cause and came with troubling side effects. I was desperate for an explanation, yet no one could provide any insights. This left me feeling even more anxious, to the point where basic tasks became overwhelming. I was terrified to sleep, use the bathroom, or even wash dishes because everything seemed to trigger the pain. I believed I’d have to adjust to a life of constant discomfort and accept that being pain-free was no longer possible. While researching solutions, I came across neuro and biofeedback therapy as a way to heal the body. I explored various options, both local and online, but after speaking with Dr. Damian on the phone and meeting him in person, I was struck by his insights and extensive experience. He was the first professional to confidently explain what was happening to me and offer a legitimate explanation. That initial conversation alone brought me a sense of relief. After exhausting all other options and spending tens of thousands of dollars, I decided to take one last leap of faith and try this therapy. Within three months of working with Dr. Damian, everything changed. I finally understood what was happening to my body and learned what it needed to heal. Dr. Damian transformed my life—not only as a provider but also as a friend, coach, and unwavering support system.

S.R. Office Visit

When it comes to chronic pain, knowledge is power. Working with Dr. Damian to gain a fundamental understanding of the complexities of my brain’s role in my pain condition literally changed my life. Dr. Damian is tremendously skillful in sharing his deep knowledge to help people like me with chronic pain conditions.

J.H. Office Visit

3

Total Reviews

5

Average Rating

All Reviews

Get In Touch

* All information subject to change. Images may contain models. Individual results are not guaranteed and may vary.